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VCU Pauley Heart Center

Physicians and staff

Fadi Salloum, PhDFadi N. Salloum, PhD, F.A.H.A.


A native of Beirut, Lebanon, Dr. Salloum earned his BS in Biology from the American University of Beirut in 1996. After graduation he served his military service in the Lebanese Army Medical Brigade.

Dr. Salloum immigrated to the United States in 1998 to pursue his Doctorate in Physiology from Virginia Commonwealth University School of Medicine. He completed his postdoctoral training in “Novel Cardioprotective Strategies against Ischemia/Reperfusion Injury” in 2008 under the mentorship of Dr. Rakesh C. Kukreja, director of the Molecular Cardiology Research Laboratories at the VCU Pauley Heart Center. He was appointed as Assistant Professor of Medicine in 2009 and promoted to Associate Professor of Medicine in 2015. He also holds an affiliate appointment in the department of Physiology & Biophysics at VCU School of Medicine.

Dr. Salloum’s investigative skills were recognized very early in his career with the American Heart Association Young Investigator Award; the Elizabeth Fries Young Investigator Award, Clinical Honorable Mention; and the American Association for the Advancement of Science, Excellence in Science Award. In 2016, Dr. Salloum received the Distinguished Research Award from the Department of Internal Medicine in recognition of meritorious research accomplishments.

As a talented and inspiring educator, he has participated in several courses offered to physiology graduate students, dental students, as well as physiology labs to first year medical students. Recently, he assumed the position of course director of PHIS 512: “Cardiac Function in Health and Disease”, which is offered by the physiology department to graduate students. This course is distinguished by its clinical focus on a variety of cardiac diseases. He has also been involved in the basic research training of numerous undergraduate and graduate students as well as cardiology fellow trainees, and currently directs the Pauley Heart Center Research Conference.

Dr. Salloum’s current research is focused on myocardial ischemia/reperfusion injury (heart attack) and heart failure. His major interest is developing novel pharmacologic strategies to combat cardiac disease and failure. His research is directed towards identifying the role of hydrogen sulfide (H 2 S) in cardioprotection against ischemia. This also includes investigations involving the harmful effects of sterile inflammation in the heart following injury, relaxin receptor signaling the context of heart disease as well as microRNAs (miRs) and their roles in cardiac health and disease. As a principal investigator, Dr. Salloum is currently funded by grants from the National Institutes of Health and Investigator Initiated Trials from Novartis Pharmaceuticals to study the potential benefits of novel pharmacotherapeutics (Serelaxin and LCZ696) in acute and chronic ischemic heart failure. Dr. Salloum was previously funded by a Grant in Aid (2014 – 2016) and National Scientist Development Grant from the American Heart Association (2010 – 2014) as well as VCU Presidential Incentive Research Program (PRIP) grant.

Dr. Salloum serves as grant reviewer for the American Heart Association – Cardiac Biology Regulation Study Group and Strategically Focused Research Network on Heart Failure, the National Institutes of Health (adhoc), the National Science Foundation (adhoc) and international funding organizations for cardiovascular research.

Dr. Salloum is also a principal investigator on a clinical research project involving evaluation of apoptosis, or programmed cell death, in patients with heart failure due to different causes, which also evaluates molecular and biochemical changes that occur due to assist device unloading. He is also co-investigator on another clinical research project involving prevention of post-infarction adverse remodeling in patients.
Dr. Salloum is a Fellow of the American Heart Association - Council on Basic Cardiovascular Sciences; and a member of the American Physiological Society- Cardiovascular Section; the International Society for Heart Research; and the American Society of Echocardiography.

He has authored or co-authored more than 83 articles that have been published in high quality peer-reviewed biomedical journals such as Circulation, Circulation Research, Journal of the American College of Cardiology, Proceedings of the National Academy of Science, Journal of Molecular and Cellular Cardiology, Molecular Pharmacology, Journal of Biological Chemistry, the American Journal of Physiology Heart and Circulatory Physiology, and several others. Additionally, he has authored or co-authored 3 book chapters, more than 100 abstracts and made numerous presentations at the American Heart Association and American College of Cardiology scientific meetings.

Dr. Salloum was appointed to the Editorial Board of PLoS One as an Academic Editor in 2011, the Editorial Board of Scientifica in 2012 and joined the Editorial Board of the American Journal of Cardiology in 2014. Dr. Salloum has served as reviewer for numerous national and international biomedical journals, which include: Journal of the American College of Cardiology, Circulation, European Heart Journal, Circulation – Heart Failure, Journal of Molecular and Cellular Cardiology, American Journal of Cardiology, American Journal of Physiology, European Journal of Heart Failure, Canadian Journal of Physiology and Pharmacology, International Journal of Cardiology, PLoS One (Public Library of Science), Cardiovascular Drugs and Therapy, Life Sciences, European Surgical Research, Journal of Urology, International Journal of Biological Sciences, International Journal of Molecular Sciences, Acta Biochimica et Biophysica Sinica, and Scientifica.

For a complete list of published work in PubMed, follow this link:




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