Physicians and staff
Stefano Toldo, PhD
Assistant Professor of Medicine
Dr. Toldo was born in Latina, Italy. In 2006, he received a MS degree in Molecular Biology from the University of Rome “La Sapienza” and in 2010 a PhD degree in Cellular and Molecular Cardiology from the Catholic University of the Sacred Heart, in Rome. Dr. Toldo joined the Pauley Heart Center in 2009 as a Research Assistant. In 2015, after five years of postdoctoral fellowship under the guidance of Dr. Antonio Abbate, he became Assistant Professor of Medicine. Dt. Toldo is part of the basic/translational research team and works closely with other physicians and scientist in the Pauley Heart Center.
The research focus of Dr. Toldo is oriented toward the understanding the mechanism by which stress signals and myocardial injury lead to activation on the local and systemic inflammatory response that affects the heart function and structure. This is particularly important because the increased presence/activity of inflammatory markers increases the risk of developing heart failure and correlates with adverse prognosis. Dr. Toldo contributed to the pioneering work led by Dr. Abbate on the discovery of the Inflammasome, a macromolecular complex that starts the inflammatory processes, in response to ischemic events in the heart. With the translational research team, he contributed to the development and characterization of blockers of the inflammasome, which are currently in preclinical testing. In recent years, Dr. Toldo has started a collaboration with the cardiothoracic surgeons at the Pauley Heart Center, to develop novel research to increase the availability of donor hearts that useful for heart transplantation.
Dr. Toldo is a member of the American Heart Association and of the Italian Society of Cardiology. He is a peer reviewer for several peer reviewed international journals, including: American Journal of Physiology, Journal of Clinical Investigation, International Journal of Cardiology, Public Library of Science (PLOSONE ), Journal of Biochemical Chemistry, Antioxidants and Redox Signaling, Journal of the American Heart Association and Experimental and Molecular Medicine.
A list of recent publications can be found at https://www.ncbi.nlm.nih.gov/sites/myncbi/1xI3ppttUWk5e/bibliography/51871678/public/?sort=date&direction=ascending.